Saccharomyces cerevisiae Catalyzed Synthesis and Evaluation of Pyrazoles

Abstract: Background: Biocatalysis in organic solvents has several benefits over aqueous solvents, including solubility of substrates, ease workup, separation the product, and, certain cases, reusability biocatalysts. Materials and Methods: A simple, effective, environmentally friendly technique for synthesizing pyrazoles been established, which involves cyclo condensation chalcones isonicotinic acid hydrazide using a relatively inexpensive catalyst baker’s yeast (Saccharomyces cerevisiae). Molecular properties prediction docking studies were also performed. Results: The predicted molecular suggest that molecules are safe oral consumption their on 2BVC-Mycobacterium tuberculosis glutamine synthetase show favorable ligand binding nature. structural assignments validated based spectrum data. compounds evaluated antitubercular, vitro anti-inflammatory, anti-oxidant effects. analysis reveals synthesized derivatives possessing methoxy, nitro, hydroxyl, fluoro, chloro substitution through phenyl ring help molecule to increase its pharmacological activities. However, substituted thiophene side chain facilitates biological action molecules. Conclusion: Anti-inflammatory, anti-oxidant, anti-tubercular due presence pyrazole ring. Keywords: Pyrazoles, Chalcones, Saccharomyces cerevisiae, In Antioxidant, Anti-tubercular.